Seismic isolation systems are one of the most important modern methods in designing earthquake-resistant buildings. These systems separate the building from the ground using flexible devices, reducing the transmission of seismic motion into the building and thus reducing potential damage. These systems include lead-reinforced rubber bearings (LRB) and sliding bearings such as the Frictional Pendulum Bearing System (FPS). Recent studies have shown the high effectiveness of seismic isolation systems in reducing base shear forces and reducing enterer floor displacement during earthquakes, which improves the safety and security of the building. Seismic isolation systems face several challenges, including the effect of soil-structure interaction (SSI), which can affect the effectiveness of the system, especially in soft soil conditions. Research shows that soil quality plays a high role in system performance, as soft soil requires special designs to achieve the desired performance. In addition, 3D seismic isolation systems have been developed to counter horizontal and vertical vibrations. These systems are vital for critical facilities such as nuclear plants, bridges, hospitals, important buildings, etc. where vertical vibrations can significantly affect the building's non-structural components and its overall stability. Although seismic isolation systems effectively reduce seismic risks, there is a continuing need for more research to develop more efficient and applicable systems in various geological and constructional conditions. The future requires a deeper understanding and development of advanced materials, adaptive control systems, and comprehensive 3D isolation solutions.